Hydroxychloroquine-induced hyperpigmentation in a 14-year-old female with systemic lupus erythematosus.
Identifieur interne : 001129 ( Main/Exploration ); précédent : 001128; suivant : 001130Hydroxychloroquine-induced hyperpigmentation in a 14-year-old female with systemic lupus erythematosus.
Auteurs : Alexander Kc Leung [Canada] ; Tara Mcmillan [Canada] ; Andrea Human [Canada] ; Joseph M. Lam [Canada]Source :
- Drugs in context [ 1745-1981 ] ; 2020.
Abstract
Hydroxychloroquine (HCQ)-induced hyperpigmentation is uncommon but is increasingly recognized. To our knowledge, HCQ-induced hyperpigmentation has not been reported in the pediatric age group. Herein, we present the case of a 14-year-old girl with systemic lupus erythematosus, who developed hyperpigmentation on her shins and dorsum of the left foot, approximately 3 years after initiating treatment with HCQ. Physicians who treat children with HCQ for reasons such as rheumatologic disorders, dermatologic disorders and, more recently, coronavirus disease-19 should be aware of this less-known side effect of HCQ.
DOI: 10.7573/dic.2020-5-8
PubMed: 32742294
PubMed Central: PMC7375853
Affiliations:
- Canada
- Alberta, Colombie-Britannique
- Calgary, Vancouver
- Université de Calgary, Université de la Colombie-Britannique
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Lam</name><affiliation wicri:level="4"><nlm:affiliation>Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><orgName type="university">Université de la Colombie-Britannique</orgName><placeName><settlement type="city">Vancouver</settlement><region type="state">Colombie-Britannique </region></placeName></affiliation></author></analytic><series><title level="j">Drugs in context</title><idno type="ISSN">1745-1981</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hydroxychloroquine (HCQ)-induced hyperpigmentation is uncommon but is increasingly recognized. To our knowledge, HCQ-induced hyperpigmentation has not been reported in the pediatric age group. Herein, we present the case of a 14-year-old girl with systemic lupus erythematosus, who developed hyperpigmentation on her shins and dorsum of the left foot, approximately 3 years after initiating treatment with HCQ. Physicians who treat children with HCQ for reasons such as rheumatologic disorders, dermatologic disorders and, more recently, coronavirus disease-19 should be aware of this less-known side effect of HCQ.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32742294</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1745-1981</ISSN><JournalIssue CitedMedium="Print"><Volume>9</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Drugs in context</Title><ISOAbbreviation>Drugs Context</ISOAbbreviation></Journal><ArticleTitle>Hydroxychloroquine-induced hyperpigmentation in a 14-year-old female with systemic lupus erythematosus.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">2020-5-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.7573/dic.2020-5-8</ELocationID><Abstract><AbstractText>Hydroxychloroquine (HCQ)-induced hyperpigmentation is uncommon but is increasingly recognized. To our knowledge, HCQ-induced hyperpigmentation has not been reported in the pediatric age group. Herein, we present the case of a 14-year-old girl with systemic lupus erythematosus, who developed hyperpigmentation on her shins and dorsum of the left foot, approximately 3 years after initiating treatment with HCQ. Physicians who treat children with HCQ for reasons such as rheumatologic disorders, dermatologic disorders and, more recently, coronavirus disease-19 should be aware of this less-known side effect of HCQ.</AbstractText><CopyrightInformation>Copyright © 2020 Leung AKC, McMillan T, Human A, Lam JM.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Leung</LastName><ForeName>Alexander Kc</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>The University of Calgary, The Alberta Children's Hospital, Calgary, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McMillan</LastName><ForeName>Tara</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Human</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lam</LastName><ForeName>Joseph M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Drugs Context</MedlineTA><NlmUniqueID>101262187</NlmUniqueID><ISSNLinking>1740-4398</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">chloroquine</Keyword><Keyword MajorTopicYN="N">dermatologic disorders</Keyword><Keyword MajorTopicYN="N">melanin</Keyword><Keyword MajorTopicYN="N">rheumatologic disorders</Keyword></KeywordList><CoiStatement>Disclosure and potential conflicts of interest: Professor Alexander KC Leung is an associate editor of Drugs in Context and confirms that this article has no conflicts of interest otherwise. This manuscript was sent out for independent peer review by the Editor-in-Chief. All other authors declare that they have no conflicts of interest relevant to this manuscript. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at: https://www.drugsincontext.com/wp-content/uploads/2020/07/dic.2020-5-8-COI.pdf</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>06</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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